Gray mouse lemurs are found throughout the dry deciduous forests and spiny deserts of the south and west from Fort-Dauphin to at least the Sambirano River.
The gray mouse lemur is one of the most widespread, abundant and adaptable lemur species. It is also among the least threatened. It is able to survive in slightly altered habitats and is therefore less threatened by occasional logging than most lemur species. It is also found in all of the protected areas within its range. There are currently over 250 gray mouse lemurs in captivity at over 50 institutions worldwide. The Duke Lemur Center houses seven individuals.