Coquerel's dwarf lemurs are squirrel sized lemurs with a long tail and horizontal body movements. They scurry through low branches in the forest by quadrupedal running and, occasionally, by leaping from branch to branch. Coquerel's dwarf lemurs live sympatrically with the fat-tailed dwarf lemur (Cheirogaleus medius) and the mouse lemur (Microcebus murinus). Despite their larger size, they are thought to be very closely related to Microcebus murinus.
Unlike their fellow small, nocturnal lemurs, the fat-tailed dwarf lemur and the mouse lemur, seasonal weight gain does not occur in this species. In the wild the animals stay about the same weight year round, and they do not enter a season of torpor.